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Multifocal Inflammatory Leukoencephalopathy Associated with Levamisole Therapy Neurol 45:374-376, Kimmel,D.W.,et al, 1995 See this aricle in Pubmed Article Abstract Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.This patient had no evidence of previous neurologic disease.Levamisole was administered for 5 weeks(total dose 1500 mg).Over a period of three weeks,the patient became progressively confused and ataxic.MRI with gadolinium enhancement demonstrated prominent multifocal enhancing white matter lesions.CSF examination revealed an inflammatory profile.After discontinuation of treatment with levamisole and a short course of corticosteroid therapy,the patient's condition dramatically improved.MRI also indicated improvement. Observations in our patient suggest t hat the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.

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(click to filter results - removes previous filter) adverse drug reaction chemotherapy,CNS treatment and complications with drug induced neurologic disorders gadolinium leukoencephalopathy levamisole MRI MRI,abnormal MRI,contrast enhanced pleocytosis of cerebrospinal fluid

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